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Photobleaching Enables Super-resolution Imaging of the FtsZ Ring in the Cyanobacterium Prochlorococcus
Published on: November 6, 2018
NIR bacteriochlorin chromophores accessed by Heck and Sonogashira cross-coupling reactions on a
Francisco F de Assis1, Marco A B Ferreira, Timothy J Brocksom
1Departamento de Química, Universidade Federal de São Carlos - UFSCar, Rodovia Washington Luíz, km 235, SP 310, 13565-905 São Carlos, SP, Brazil. kleber.oliveira@ufscar.br.
Abstract:
The synthesis of a new tetrabromobacteriochlorin BCBr4 is reported having the 3,4-dibromo-1H-pyrrole-2-carbaldehyde (10) as the major precursor. The BCBr4 was successfully employed in Pd cross-coupling reactions with methyl acrylate, phenyl acetylene and 4-ethynylanisole. In all three cases, the desired tetra-coupled products were obtained in good to excellent yields, and present a significant red shift in the UV-Vis bands above 800 nm. DFT and TD-DFT theoretical analyses of the NIR bacteriochlorin chromophores were performed in order to evaluate the effect of β substitution on their electronic structures.
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