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Acute lymphoblastic leukemia presenting with bilateral serous macular detachment
Luisa Vieira1, Nuno Aguiar Silva1, Marco Dutra Medeiros1
1Central Lisbon Hospital Center, Lisbon, Portugal.
Arquivos Brasileiros De Oftalmologia
|December 18, 2015
Summary
Ocular fundus alterations, specifically bilateral macular serous detachment, can be the initial presentation of adult acute lymphoblastic leukemia (ALL). Prompt diagnosis and chemotherapy led to complete remission and resolution of eye symptoms.
Area of Science:
- Ophthalmology
- Hematology
- Oncology
Background:
- Acute lymphoblastic leukemia (ALL) is a rare adult malignancy.
- Ocular manifestations are known complications but seldom present as initial symptoms.
Observation:
- A patient presented with progressive vision loss, fever, and lymphadenopathy.
- Fundus examination revealed bilateral macular serous detachment, confirmed by OCT and fluorescein angiography.
Findings:
- Blood count abnormalities prompted further investigation.
- The patient was diagnosed with B-cell acute lymphoblastic leukemia (CD10+).
Implications:
- This case highlights the importance of considering hematologic malignancies in patients with unexplained visual disturbances.
- Early detection through ophthalmologic findings can lead to timely diagnosis and treatment of ALL.
- Successful treatment resulted in complete remission and resolution of ocular symptoms.
