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Updated: Mar 28, 2026
08:50
Longitudinal Morphological and Physiological Monitoring of Three-dimensional Tumor Spheroids Using Optical Coherence Tomography
Published on: February 9, 2019
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[Technical principles of OCT angiography].
P P Fang1, W M Harmening1, P L Müller1
1Universitäts-Augenklinik Bonn, Ernst-Abbe-Str. 2, 53127, Bonn, Deutschland.
Summary
Optical coherence tomography angiography (OCT-A) provides non-invasive, 3D visualization of retinal and choroidal vasculature. This advanced OCT technology enables detailed perfusion analysis and is now clinically applicable for detecting vascular alterations.
Area of Science:
- Ophthalmology
- Medical Imaging
- Angiography
Background:
- Optical coherence tomography angiography (OCT-A) is an advanced, non-invasive imaging technique.
- It visualizes retinal and choroidal vascular structures in 3D without contrast dyes.
- OCT-A builds upon OCT technology, enabling both morphological and perfusion analyses.
Purpose of the Study:
- To discuss the principles and applications of OCT-A.
- To compare OCT-A with other non-invasive diagnostic devices for retinal and choroidal circulation.
- To highlight the clinical utility of OCT-A.
Main Methods:
- Selective literature review.
- Analysis of own data.
Main Results:
- OCT-A offers easy application, avoiding mydriasis and dye injections.
- It provides precise 3D localization of vascular changes.
- Software segmentation in retinal pathologies may differ from actual retinal architecture, requiring clinical consideration.
Conclusions:
- OCT-A is the only non-invasive device currently suitable for routine clinical use in visualizing retinal and choroidal circulation.
- This technology allows depth-selective visualization of alterations.
- OCT-A overcomes masking effects like pooling or staining seen with other methods.
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