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Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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Isolation And Dendritic Cell-Uptake of Small Extracellular Vesicles from Echinococcus granulosus
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SLE-associated risk factors affect DC function.

Myoungsun Son1, Sun Jung Kim1, Betty Diamond1

  • 1The Feinstein Institute for Medical Research, Center for Autoimmune and Musculoskeletal Diseases, Manhasset, NY, USA.

Immunological Reviews
|December 20, 2015
PubMed
Summary
This summary is machine-generated.

Systemic lupus erythematosus (SLE) risk genes are highly expressed in B cells and dendritic cells (DCs). Dysfunctional DCs can drive autoimmunity, highlighting their role in SLE pathogenesis.

Keywords:
dendritic cellsimmune tolerancerisk allelessystemic lupus

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Area of Science:

  • Immunology
  • Autoimmunity
  • Genetics

Background:

  • Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by autoantibodies.
  • Numerous genetic risk factors for SLE have been identified.
  • Risk gene expression is concentrated in B cells and dendritic cells (DCs), suggesting their critical role.

Purpose of the Study:

  • To review the mechanisms of tolerance that maintain dendritic cells (DCs) in a non-activated state.
  • To explore how alterations in DC function contribute to the development of autoimmunity in SLE.
  • To highlight the role of DCs in bridging innate and adaptive immunity in SLE.

Main Methods:

  • Analysis of gene expression in hematopoietic cells.
  • Review of existing literature on DC function and tolerance.
  • Presentation of experimental examples illustrating DC dysfunction in autoimmunity.

Main Results:

  • Risk alleles associated with SLE are predominantly expressed in B cells and DCs.
  • DCs are central to immune responses, linking innate and adaptive immunity.
  • Aberrations in DC-intrinsic or extrinsic regulation can lead to autoimmune predispositions.

Conclusions:

  • Dendritic cells (DCs) are key players in the pathogenesis of systemic lupus erythematosus (SLE).
  • Maintaining DC tolerance is crucial for preventing autoimmunity.
  • Understanding DC dysfunction offers potential therapeutic targets for SLE.