The Corticocortical Structural Connectivity of the Human Insula
Jimmy Ghaziri1,2, Alan Tucholka2,3,4,5, Gabriel Girard6
1Département de Neurosciences.
Cerebral Cortex (New York, N.Y. : 1991)
|December 20, 2015
Summary
This study mapped human brain connections using advanced imaging. It reveals novel structural connectivity between the insula and cingulate cortex, crucial for brain function.
Area of Science:
- Neuroscience
- Human Brain Connectivity
- Neuroimaging
Background:
- The insula is a key brain region with diverse functions.
- Previous studies showed extensive connections in primates but lacked human data for insula-cingulate pathways.
Purpose of the Study:
- To investigate the structural connectivity of the human insula.
- To clarify the insula's connections with other brain regions, particularly the cingulate cortex.
Main Methods:
- High angular resolution diffusion imaging (HARDI) tractography was used.
- Analysis was performed on 46 healthy young adults with anatomical priors.
Main Results:
- Confirmed widespread insula connections across frontal, temporal, parietal, and occipital lobes.
- Demonstrated novel structural connectivity between the insula and cingulate cortex in humans.
- Identified connections with parahippocampal, supramarginal, angular gyri, precuneus, and occipital regions.
Conclusions:
- Advanced HARDI tractography provides detailed human brain connectomics.
- Established direct structural links between the insula and cingulate cortex, supporting functional theories.
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