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Updated: Mar 28, 2026

Collection and Extraction of Saliva DNA for Next Generation Sequencing
Published on: August 27, 2014
The Neonatal Salivary Transcriptome
1Department of Pediatrics, Mother Infant Research Institute, Tufts Medical Center, Boston, Massachusetts 02111.
Abstract:
The ability to noninvasively assess the physical and developmental status of a neonate is a goal of modern medicine. In recent years, technological advances have permitted the high-throughput analysis of saliva for thousands of genes, proteins, and metabolites from a single sample source. Saliva is an ideal biofluid to assess health, disease, and development in the newborn. It may be harnessed repeatedly, even in the most vulnerable patients, without risk of harm. Translating novel information about an infant's global development and risk of disease to the neonatal bedside through the salivary transcriptome has the potential to significantly improve clinical care and outcomes in this at-risk population.
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