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Updated: Mar 28, 2026
Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
Published on: December 14, 2020
[An association between adenoid hypertrophy and exstra-gastroesophageal reflux disease]
Insights
Adenoid hypertrophy in children may be linked to extra-gastroesophageal reflux. Pepsin from reflux may damage the upper airway, contributing to this condition.
Area of Science:
- Pediatrics
- Otolaryngology
- Gastroenterology
Background:
- Adenoid hypertrophy is common in children aged 3-5 years.
- Pathological hyperplasia of adenoid results from repeated inflammation and infection.
- The specific mechanism of adenoid hypertrophy remains unclear.
Purpose of the Study:
- To review the relationship between gastroesophageal reflux and adenoid hypertrophy.
- To explore the potential role of pepsin in adenoid hypertrophy pathogenesis.
Main Methods:
- Literature review of domestic and international studies.
- Analysis of research on extra-gastroesophageal reflux and upper airway conditions.
Main Results:
- Emerging research suggests a link between adenoid hypertrophy and extra-gastroesophageal reflux.
- Pepsin, a component of refluxate, is implicated in pathological damage to the upper airway.
Conclusions:
- Extra-gastroesophageal reflux, particularly the role of pepsin, is a potential contributing factor to adenoid hypertrophy.
- Further research is warranted to elucidate the precise mechanisms involved.
Abstract:
Adenoid hypertrophy is a disease that mostly occurs among children of 3-5 years old. It is caused by repeated inflammation and infection of nasopharynx and its adjoin parts, or the adenoid itself, which will finally leads to pathological hyperplasia of adenoid. With so much information we have acquired about this disease, its specific mechanism remains unknown. In recent years, some researches have indicated that adenoid hypertrophy may have something to do with extra-gastroesophageal reflux, in which pepsin plays a very important role, and pepsin will do a series of pathological damages to the upper airway as it reaches the upper respiratory tract. Based on relative domestic and foreign literature, this paper attempts to make a review about the relationship between gastroesophageal reflux and adenoid hypertrophy.
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