Synthesis, cytotoxicity and anti-cancer activity of new alkynyl-gold(I) complexes
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Updated: Oct 6, 2026

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
Published on: November 10, 2013
Assunta De Nisi1, Christian Bergamini, Marco Leonzio
1Department of Chemistry "G. Ciamician", Alma Mater Studiorum - University of Bologna, Via Selmi 2, 40126 Bologna, Italy. marco.bandini@unibo.it.
Abstract:
Alkynyl(triphenylphosphine)gold(i) complexes carrying variously substituted propargylic amines have been synthesized and fully characterized in solution and solid state. High levels of toxicity (i.e. micromolar range) were recognized for a series of cancer cell lines with particular emphasis on HT29, IGROV1, HL60 and I407. In particular the lead compound 3ab was identified as the most active compound in all cell lines (IC50: 1.7-7.9 μM).

