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Microbial Corrosion01:24

Microbial Corrosion

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Microbiologically Influenced Corrosion (MIC) is a significant form of material degradation caused by the metabolic activities of microorganisms. This phenomenon poses substantial challenges across various industries, including oil and gas, maritime, and water treatment sectors.MIC occurs when microorganisms, such as bacteria, archaea, and fungi, colonize metal surfaces, forming biofilms that alter the local electrochemical environment. These biofilms can lead to the production of corrosive...
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Tooth Anatomy01:21

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The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
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Role of Matrix Metalloproteases in Degradation of ECM01:23

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Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult...
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Biodeterioration01:28

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Biodeterioration refers to the unwanted alteration of materials caused by microorganisms—especially fungi—which damage both organic substrates (paper, wood, textiles) and inorganic ones (stone, plaster, glass). Unlike abiotic decay, biodeterioration results from biological activity that produces physical disruption and chemical degradation.Physical deterioration occurs as fungal hyphae penetrate pores, cracks, and surface irregularities. Hyphal turgor pressure, thigmotropic growth...
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The Oral Microbiota01:27

The Oral Microbiota

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The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
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Bacterial Phylum Actinobacteria01:30

Bacterial Phylum Actinobacteria

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Coryneform bacteria are gram-positive, aerobic, nonmotile rods that exhibit irregular, club-shaped, or V-shaped arrangements. Their V-shape results from snapping division, where the inner cell wall layer forms the cross-wall, while the outer layer remains intact until it ruptures on one side, causing the daughter cells to bend away.The primary genera are Corynebacterium and Arthrobacter. Corynebacterium includes diverse species, ranging from saprophytes to pathogens like Corynebacterium...
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Related Experiment Video

Updated: Mar 28, 2026

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries
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DENTINE CARIES: ACID-TOLERANT MICROORGANISMS AND ASPECTS ON COLLAGEN DEGRADATION.

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    Summary
    This summary is machine-generated.

    Dental caries involves acid-producing microbes and carbohydrate metabolism. This study investigates dentine caries microbiota and host-derived enzymes, revealing unique microbial compositions and elevated matrix metalloproteinase-8 in carious lesions.

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    Area of Science:

    • Oral microbiology
    • Biochemistry
    • Dental research

    Background:

    • Dental caries is a global disease caused by oral microorganisms metabolizing carbohydrates into acids.
    • Dentine caries lesions present a unique environment for microorganisms compared to enamel biofilm.
    • Understanding dentine caries microbiology and host-derived enzyme involvement is crucial for developing new treatment strategies.

    Purpose of the Study:

    • To enumerate and characterize microorganisms in established dentine caries lesions.
    • To investigate the role of host-derived proteolytic enzymes in dentine degradation.
    • To explore new methods for influencing the progression of caries lesions.

    Main Methods:

    • Cultivation of carious dentine samples on various agar media under different atmospheric and pH conditions.
    • Analysis of microbial colony-forming units (CFUs) and species composition.
    • Quantification of salivary matrix metalloproteinase-8 (MMP-8) and tissue inhibitor of MMP (TIMP-1) levels.

    Main Results:

    • Microorganisms were found to remain in cavity floors even after excavation, regardless of the method used.
    • Each dentine caries lesion harbored a unique acid-tolerant microbiota.
    • Significantly elevated salivary MMP-8 levels were observed in subjects with manifest caries lesions.

    Conclusions:

    • Operative caries removal methods leave viable microorganisms, highlighting the need for further investigation.
    • Dentine caries lesions are colonized by diverse aciduric microorganisms, indicating complex survival mechanisms.
    • Elevated MMP-8 levels suggest a potential role for host-derived enzymes in dentine caries progression, offering targets for future interventions.