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Updated: Mar 28, 2026
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Histological changes caused by meclofenamic acid in androgen-independent prostate cancer tumors: evaluation in a
Iván Delgado-Enciso1,2, Alejandro D Soriano-Hernández1, Alejandrina Rodriguez-Hernandez1
1School of Medicine, University of Colima, Colima, México.
Abstract:
Meclofenamic acid is a nonsteroidal anti-inflammatory drug that has shown therapeutic potential for different types of cancers, including androgen-independent prostate neoplasms. The antitumor effect of diverse nonsteroidal anti-inflammatory drugs has been shown to be accompanied by histological and molecular changes that are responsible for this beneficial effect. The objective of the present work was to analyze the histological changes caused by meclofenamic acid in androgen-independent prostate cancer. Tumors were created in a nude mouse model using PC3 cancerous human cells. Meclofenamic acid (10 mg/kg/day; experimental group, n=5) or saline solution (control group, n=5) was administered intraperitoneally for twenty days. Histological analysis was then carried out on the tumors, describing changes in the cellular architecture, fibrosis, and quantification of cellular proliferation and tumor vasculature. Meclofenamic acid causes histological changes that indicate less tumor aggression (less hypercellularity, fewer atypical mitoses, and fewer nuclear polymorphisms), an increase in fibrosis, and reduced cellular proliferation and tumor vascularity. Further studies are needed to evaluate the molecular changes that cause the beneficial and therapeutic effects of meclofenamic acid in androgen-independent prostate cancer.
Insights
Meclofenamic acid reduced aggression in androgen-independent prostate cancer models. This nonsteroidal anti-inflammatory drug decreased tumor cell proliferation and vascularity, indicating therapeutic potential.
Area of Science:
- Oncology
- Pharmacology
Background:
- Nonsteroidal anti-inflammatory drugs (NSAIDs) show therapeutic potential for various cancers.
- NSAIDs exert antitumor effects through histological and molecular changes.
- Androgen-independent prostate cancer remains a challenging therapeutic target.
Purpose of the Study:
- To investigate the histological alterations induced by meclofenamic acid in androgen-independent prostate cancer.
- To assess the impact of meclofenamic acid on tumor aggression markers.
Main Methods:
- A nude mouse model was utilized, implanting PC3 human prostate cancer cells.
- Mice received daily intraperitoneal injections of meclofenamic acid (10 mg/kg) or saline for 20 days.
- Histological analysis evaluated cellular architecture, fibrosis, proliferation, and vascularity.
Main Results:
- Meclofenamic acid treatment led to reduced tumor aggression, characterized by decreased hypercellularity, atypical mitoses, and nuclear polymorphisms.
- Significant increases in tumor fibrosis were observed in the meclofenamic acid group.
- Meclofenamic acid administration resulted in reduced cellular proliferation and tumor vascularity.
Conclusions:
- Meclofenamic acid induces histological changes indicative of decreased tumor aggression in androgen-independent prostate cancer.
- The drug's effects include increased fibrosis and reduced proliferation and vascularity.
- Further research into the molecular mechanisms underlying these therapeutic effects is warranted.
