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Updated: Mar 28, 2026

Self-Assembly of Hybrid Lipid Membranes Doped with Hydrophobic Organic Molecules at the Water/Air Interface
Published on: May 1, 2020
Hybrid Fluorinated and Hydrogenated Double-Chain Surfactants for Handling Membrane Proteins
Fréderic Legrand1, Cécile Breyton2,3,4, Pierre Guillet1
1Institut des Biomolécules Max Mousseron UMR 5247 CNRS-Université Montpellier-ENSCM & Avignon Université , Equipe Chimie Bioorganique et Systèmes Amphiphiles, 301 rue Baruch de Spinoza BP 21239, 84916 Cedex 9 Avignon, France.
Abstract:
Two hybrid fluorinated double-chain surfactants with a diglucosylated polar head were synthesized. The apolar domain consists of a perfluorohexyl main chain and a butyl hydrogenated branch as a side chain. They were found to self-assemble into small micelles at low critical micellar concentrations, demonstrating that the short branch increases the overall hydrophobicity while keeping the length of the apolar domain short. They were both able to keep the membrane protein bacteriorhodopsin stable, one of them for at least 3 months.
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