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Updated: Mar 28, 2026

The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy
Published on: June 1, 2019
[Focus on methods for detection of sentinel nodes in breast cancer]
E Cohen1, A Bricou1, J Boujenah1
1Service de gynécologie-obstétrique, AP-HP, Jean-Verdier, université Paris XIII - Bobigny, avenue du 14-Juillet, 93143 Bondy cedex, France.
Abstract:
The sentinel node procedure (GS) is the recommended technique for axillary surgical exploration in localized breast cancer with no clinical or radiological lymph node involvement. This surgical technique is based on a dual isotope and colorimetric detection. Although it allows a significant reduction in morbidity compared to axillary dissection (CA), this procedure induces a number of organizational constraints, in particular for the radioisotope injection. Specially for this reason, other GS methods have emerged in recent years, some of which appear promising (detection by fluorescence and magnetic iron). The objective of this paper was to carry out a synthesis of the reference method of detection (radioisotope) GS and analyze the recent literature on new detection methods.

