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Blastomycosis
1Department of Dermatology, Cleveland Clinic Foundation, Ohio.
Dermatologic Clinics
|April 1, 1989
Summary
Blastomycosis, a fungal infection, can be fatal but may resolve on its own. While amphotericin B is the primary treatment, imidazole drugs like ketoconazole show promise for treating this rare disease.
Area of Science:
- Mycology
- Infectious Diseases
- Medical Mycology
Background:
- Blastomycosis is an uncommon infectious disease.
- It is caused by the fungus Blastomyces dermatitidis.
- The disease course can range from self-healing to fatal.
Purpose of the Study:
- To review the treatment options for blastomycosis.
- To highlight the efficacy of imidazole drugs in blastomycosis treatment.
Main Methods:
- Literature review of antifungal treatments.
- Analysis of clinical data on blastomycosis therapy.
Main Results:
- Amphotericin B remains the established drug of choice for blastomycosis.
- Imidazole antifungals, including ketoconazole, miconazole, itraconazole, and econazole, demonstrate therapeutic potential.
Conclusions:
- Imidazole drugs represent a promising alternative or adjunctive therapy for blastomycosis.
- Further research may solidify the role of these antifungals in clinical practice.