[Functional classification of allergic diseases].

Area of Science:

• Clinical immunology
• Immunopathology
• Allergology

Context:

• Allergic reactions follow established immunological principles from antigen presentation to effector mechanisms.
• The classical Coombs' and Gell classification of allergic reactions is widely recognized.
• Understanding the cellular and molecular basis of allergic responses is crucial in immunology.

Purpose:

• To propose an expansion of the classical Coombs' and Gell classification of allergic reactions.
• To introduce a functional classification system for allergic reactions.
• To integrate T- and B-lymphocyte involvement and immunoglobulin roles into allergy classification.

Summary:

• Allergology, the oldest branch of clinical immunology, examines allergic reactions.
• Allergic reactions adhere to general immune response laws, involving antigen presentation and effector mechanisms.
• The study suggests augmenting the four classical Coombs' and Gell types of allergy with a functional classification based on T- and B-lymphocytes and involved immunoglobulins.

Impact:

• This functional classification provides a more comprehensive understanding of allergic pathogenesis.
• It facilitates a deeper insight into the roles of specific lymphocytes and immunoglobulins in allergic diseases.
• The proposed classification can aid in developing more targeted diagnostic and therapeutic strategies in allergology and clinical immunology.