[In Situ Polymerization and Characterization of Hydroxyapatite/polyurethane Implanted Material].

Area of Science:

• Biomaterials Science
• Polymer Chemistry
• Nanotechnology

Background:

• Hydroxyapatite/polyurethane composites are promising for implanted materials.
• Improving interfacial bonding and hydroxyapatite dispersion is crucial for enhanced properties.
• Current methods may have limitations in achieving optimal composite performance.

Purpose of the Study:

• To synthesize nano-hydroxyapatite/polyurethane composites via in situ polymerization.
• To enhance interfacial bonding strength and hydroxyapatite dispersion within the polyurethane matrix.
• To evaluate the cytocompatibility and mechanical properties of the developed composites.

Main Methods:

• In situ polymerization technique for composite synthesis.
• Characterization of fracture morphology, thermal stability, and glass transition temperature.
• Mechanical testing including tensile strength and maximum elongation.
• In vitro cytocompatibility assessment using MG63 cells.

Main Results:

• In situ polymerization successfully improved interfacial bonding and hydroxyapatite dispersion.
• Composites with 20 wt% hydroxyapatite exhibited enhanced thermal stability and increased glass transition temperatures.
• Significant improvements in tensile strength (236.45%) and maximum elongation (143.30%) were observed compared to pure polyurethane.
• Composites demonstrated positive effects on MG63 cell adhesion and proliferation.

Conclusions:

• In situ polymerization is an effective method for producing nano-hydroxyapatite/polyurethane composites with superior properties.
• The developed composites show promise as biomaterials due to enhanced mechanical and thermal characteristics.
• The cytocompatibility of the composites supports their potential for biomedical applications, particularly in tissue engineering and implants.