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Related Concept Videos

The Oral Microbiota01:27

The Oral Microbiota

The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
Oral Drug Delivery Systems: Introduction01:23

Oral Drug Delivery Systems: Introduction

Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
Development of the Oral Microbiota01:28

Development of the Oral Microbiota

The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are employed to...
Microbial Corrosion01:24

Microbial Corrosion

Microbiologically Influenced Corrosion (MIC) is a significant form of material degradation caused by the metabolic activities of microorganisms. This phenomenon poses substantial challenges across various industries, including oil and gas, maritime, and water treatment sectors.MIC occurs when microorganisms, such as bacteria, archaea, and fungi, colonize metal surfaces, forming biofilms that alter the local electrochemical environment. These biofilms can lead to the production of corrosive...
Teeth01:15

Teeth

The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...

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Updated: May 23, 2026

Use of a High-throughput In Vitro Microfluidic System to Develop Oral Multi-species Biofilms
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Advances in Nanozyme Engineering for Precision Oral Health Management.

Fan Tong1, Feifei Feng2, Lingyi Zhang1

  • 1College of Traditional Chinese Medicine, Jilin Agriculture Science and Technology College, Jilin, China.

International Dental Journal
|May 21, 2026
PubMed
Summary
This summary is machine-generated.

Nanozymes offer advanced precision for oral diseases, targeting bacteria and aiding tissue repair. These novel therapeutics promise improved outcomes and reduced antibiotic use in dentistry.

Keywords:
Drug delivery platformNanozymesOral DiseasesTissue repair

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Last Updated: May 23, 2026

Use of a High-throughput In Vitro Microfluidic System to Develop Oral Multi-species Biofilms
07:09

Use of a High-throughput In Vitro Microfluidic System to Develop Oral Multi-species Biofilms

Published on: December 1, 2014

Nanosensors to Detect Protease Activity In Vivo for Noninvasive Diagnostics
10:50

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Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries
08:20

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

Published on: March 31, 2021

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Oral Medicine

Background:

  • Traditional dental treatments face challenges like poor targeting and limited regenerative capacity.
  • There is a need for advanced therapeutic systems in oral medicine.

Purpose of the Study:

  • To review nanozyme applications for oral diseases.
  • To highlight nanozymes' advantages over conventional methods.
  • To provide a basis for precision oral therapeutic systems.

Main Methods:

  • Comprehensive literature search of PubMed, Web of Science, and core databases.
  • Inclusion of in vitro, in vivo, and clinical studies on nanozymes in oral diseases.

Main Results:

  • Nanozymes show potential in targeted antibacterial therapy, oxidative stress regulation, and oral tissue repair.
  • Integration with delivery platforms enhances therapeutic precision.
  • Nanozymes offer a dynamic approach to managing biofilm-associated diseases and complex oral conditions.

Conclusions:

  • Nanozymes represent a paradigm shift in oral therapeutics.
  • Future research should focus on synergistic systems, biocompatibility, and clinical translation.
  • Nanozymes hold promise for precision oral medicine, reducing antibiotic reliance and improving treatment outcomes.