Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein Glycosylation01:25

Protein Glycosylation

10.4K
Glycosylation, the most common post-translational modification for proteins, serves diverse functions. Adding sugars to proteins makes the proteins more resistant to proteolytic digestion. Glycosylated proteins can act as markers and receptors to promote cell-cell adhesion. Additionally, they have many essential quality control functions in the cell, such as correct protein folding and facilitating transport of misfolded proteins to the cytosol, which can be degraded.
Glycosylation occurs in...
10.4K
Proteoglycans01:05

Proteoglycans

5.1K
Glycans, a class of complex heterogeneous molecules, can be covalently attached to proteins to form glycosylated proteins that regulate various physiological and pathological processes. Glycosylated proteins or glycoproteins comprise N-linked and O-linked oligosaccharides. O-glycosylation is the most common type of protein glycosylation. Here, glycans attach to the oxygen atom of the hydroxyl groups of Serine or Threonine residues. O-linked glycosylation occurs later in protein processing,...
5.1K
Oligosaccharide Assembly01:24

Oligosaccharide Assembly

3.8K
Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...
3.8K
Multiple Allele Traits01:49

Multiple Allele Traits

38.7K
The Concept of Multiple Allelism
38.7K
Pleiotropy01:33

Pleiotropy

44.0K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
44.0K
Glycocalyx and its Functions01:14

Glycocalyx and its Functions

10.3K
The glycocalyx is a carbohydrate-rich, fuzzy-appearing layer on the outer surface of the cell membrane. It is highly hydrophilic, because of this it attracts large amounts of water to the cell's surface. This aids the cell's interaction with the watery environment and also helps it to obtain substances dissolved in the water. It is also important for cell identification, self/non-self determination, and embryonic development and is used in cell-to-cell attachments to form tissues.
10.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multinational Consensus: Insulin Initiation with Insulin Degludec/Aspart (IDegAsp).

Advances in therapy·2018
Same author

The Berlin Declaration: A call to improve early actions related to type 2 diabetes. Why is primary care important?

Primary care diabetes·2018
Same author

Thoughts, Words, Action: The Alma-Ata Declaration to Diabetes Care Transformation.

Diabetes therapy : research, treatment and education of diabetes and related disorders·2018
Same author

Basal Insulin Inadequacy versus Failure - Using Appropriate Terminology.

European endocrinology·2018
Same author

Lessons From LEADER - All-round Leadership.

European endocrinology·2018
Same author

Beta-cell Insufficiency.

European endocrinology·2018
Same journal

Predictors of Altmetric Score in Top-Cited Orthopaedic Articles: A Bibliometric Analysis.

JPMA. The Journal of the Pakistan Medical Association·2026
Same journal

Carbon footprint of waste generated in orthopaedic cases in Pakistan: a pilot descriptive study.

JPMA. The Journal of the Pakistan Medical Association·2026
Same journal

Enhancing quotation accuracy assessment with Chatpdf - a game-changer for a century-old conundrum.

JPMA. The Journal of the Pakistan Medical Association·2026
Same journal

Barriers to implementing simulation-based surgical training for improving quality and safety in developing countries: A short communication.

JPMA. The Journal of the Pakistan Medical Association·2026
Same journal

Intraoperative Adverse Event Reporting in Gastrointestinal Cancer Surgery: A Narrative Review on the Application of ClassIntra.

JPMA. The Journal of the Pakistan Medical Association·2026
Same journal

The Impact of Mortality and Morbidity Meetings on Quality Improvement and Patient Safety.

JPMA. The Journal of the Pakistan Medical Association·2026
See all related articles

Related Experiment Video

Updated: Mar 28, 2026

Glycan Node Analysis: A Bottom-up Approach to Glycomics
11:36

Glycan Node Analysis: A Bottom-up Approach to Glycomics

Published on: May 22, 2016

11.3K

The gluco-phenotype.

Sanjay Kalra1, Yashdeep Gupta2

  • 1Department of Endocrinology, Bharti Hospital, Karnal, India.

JPMA. the Journal of the Pakistan Medical Association
|December 30, 2015
PubMed
Summary
This summary is machine-generated.

Understanding the gluco-phenotype is key for characterizing glycemic status and planning diabetes management. This involves detailed patient history, physical exams, and assessing key glycemic parameters like HbA1c.

Keywords:
Diabetes, person-centered care, individualized care, insulin, premixed insulin, prandial insulin, basal insulin.

More Related Videos

Identification and Characterization of Protein Glycosylation using Specific Endo- and Exoglycosidases
09:54

Identification and Characterization of Protein Glycosylation using Specific Endo- and Exoglycosidases

Published on: December 26, 2011

37.7K
Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments
10:59

Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments

Published on: February 7, 2025

1.9K

Related Experiment Videos

Last Updated: Mar 28, 2026

Glycan Node Analysis: A Bottom-up Approach to Glycomics
11:36

Glycan Node Analysis: A Bottom-up Approach to Glycomics

Published on: May 22, 2016

11.3K
Identification and Characterization of Protein Glycosylation using Specific Endo- and Exoglycosidases
09:54

Identification and Characterization of Protein Glycosylation using Specific Endo- and Exoglycosidases

Published on: December 26, 2011

37.7K
Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments
10:59

Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments

Published on: February 7, 2025

1.9K

Area of Science:

  • Endocrinology and Metabolism
  • Clinical Diagnostics

Background:

  • Dysglycaemia presents a complex challenge in metabolic health.
  • Characterizing an individual's glycemic status is crucial for effective management.

Purpose of the Study:

  • To introduce and define the concept of gluco-phenotype.
  • To highlight the importance of gluco-phenotype in understanding dysglycaemia.
  • To outline a framework for personalized diabetes management.

Main Methods:

  • Detailed patient history taking.
  • Comprehensive physical examination.
  • Assessment of key glycaemic parameters: fasting glucose, postprandial glucose, and HbA1c.

Main Results:

  • The gluco-phenotype integrates clinical and biochemical data.
  • It aids in characterizing an individual's specific glycaemic status.
  • It facilitates understanding the etio-pathogenesis of dysglycaemia.

Conclusions:

  • The gluco-phenotype is essential for personalized diabetes care.
  • A thorough clinical and biochemical assessment is fundamental.
  • Effective diabetes management relies on a comprehensive understanding of the individual's gluco-phenotype.