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Related Experiment Video

Updated: Mar 28, 2026

An Electrochemical Cholesteric Liquid Crystalline Device for Quick and Low-Voltage Color Modulation

An Electrochemical Cholesteric Liquid Crystalline Device for Quick and Low-Voltage Color Modulation

Published on: February 27, 2019

Highly sensitive color-indicating and quantitative biosensor based on cholesteric liquid crystal.

Yu-Cheng Hsiao¹, Yu-Chien Sung¹, Mon-Juan Lee²

¹Institute of Imaging and Biomedical Photonics, College of Photonics, National Chiao Tung University, Guiren Dist., Tainan 71150, Taiwan.

Biomedical Optics Express

|December 30, 2015

Summary

Cholesteric liquid crystals (CLCs) offer a novel biosensing platform. This study demonstrates CLCs for highly sensitive, naked-eye detection of bovine serum albumin (BSA) with a 1 fg/ml limit, advancing point-of-care diagnostics.

Keywords:

(160.1585) Chiral media (160.3710) Liquid crystals (170.0170) Medical optics and biotechnology (230.3720) Liquid-crystal devices

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Area of Science:

Biomolecular Interaction Analysis
Materials Science
Nanotechnology

Background:

Liquid crystal (LC)-based biosensors leverage sensitive interfaces for biomolecule detection.
Current nematic LC biosensors face limitations in quantitative reproducibility and reliability.
Improvements in accuracy and reliability are needed for LC-based detection techniques.

Purpose of the Study:

To introduce cholesteric liquid crystals (CLCs) as a novel sensing element for biosensing.
To demonstrate the use of CLCs for detecting bovine serum albumin (BSA).
To develop a highly sensitive and visually indicative biosensing platform.

Main Methods:

Utilizing the chirality of vertically anchored (VA) CLCs for biomolecule detection.
Exploiting changes in color appearance and transmission spectra of CLC phases.
Quantifying the detection limit for bovine serum albumin (BSA).

Main Results:

A detection limit of 1 fg/ml for BSA was achieved using VA CLCs.
The color and transmission spectrum of the CLC phase correlated with BSA concentration.
The VA CLC interface demonstrated a significant optical response to BSA.

Conclusions:

Cholesteric liquid crystals provide a simple, inexpensive platform for sensitive biosensing.
The naked-eye color indication facilitates practical diagnostic applications.
This approach may accelerate the development of point-of-care devices for biomarker detection.