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Published on: September 22, 2020
Preoperative Platelet to Lymphocyte Ratio Is Associated with Early Morbidity and Mortality after Coronary Artery
Hüseyin Şaşkın1, Çagrı Düzyol1, Kazım Serhan Özcan2
1Department of Cardiovascular Surgery, Derince Training and Research Hospital, Kocaeli, Turkey.
Insights
Elevated platelet to lymphocyte ratio (PLR) is linked to increased mortality and morbidity following coronary artery bypass grafting (CABG) surgery. This finding highlights PLR as a significant predictor of adverse outcomes in cardiac patients.
Area of Science:
- Cardiology
- Hematology
- Surgical Outcomes
Background:
- Coronary artery bypass grafting (CABG) is a major cardiac surgery.
- Identifying predictors of post-operative mortality and morbidity is crucial for patient management.
Purpose of the Study:
- To investigate the association between the platelet to lymphocyte ratio (PLR) and outcomes after CABG.
- To determine if PLR is an independent risk factor for adverse events post-CABG.
Main Methods:
- Retrospective analysis of 916 patients undergoing CABG between January 2009 and May 2014.
- Patients were stratified into two groups based on pre-operative PLR: Group 1 (PLR > 142) and Group 2 (PLR <= 142).
Main Results:
- Group 2 (lower PLR) had a significantly higher incidence of neurologic events (3.8% vs 1.2%, P = .007) and early mortality (3.2% vs 0.5%, P = .001).
- Preoperative PLR was identified as an independent risk factor for atrial fibrillation, sternal dehiscence reoperation, neurologic events, prolonged hospital stay, and mortality.
Conclusions:
- Elevated pre-operative platelet to lymphocyte ratio is associated with increased mortality and morbidity after coronary artery bypass grafting.
- PLR serves as a valuable predictive marker for adverse outcomes in patients undergoing CABG.
Objective:
To investigate the association of platelet to lymphocyte ratio to mortality and morbidity after coronary artery bypass grafting operation.
Methods:
We evaluated records of 916 patients who underwent coronary artery bypass grafting operation between January 2009 and May 2014 retrospectively. Patients were grouped as Group 1 (n = 604) if the platelet to lymphocyte ratio was above 142 and Group 2 (n = 312) if platelet to lymphocyte ratio was below 142.
Results:
The number of patients who developed a neurologic event during the hospital stay and in the first postoperative month was 7 (1.2%) in Group 1 and 12 (3.8%) in Group 2 for which the difference was statistically significant (P = .007). Early term mortality occurred in 3 patients (0.5%) in Group 1 and in 10 patients (3.2%) in Group 2 for which the difference was statistically highly significant (P = .001). In univariate and multivariate regression analysis, the preoperative platelet to lymphocyte ratio was determined as an independent risk factor for occurrence of atrial fibrillation in the early postoperative period, reoperation for sternum dehiscence, occurrence of a neurologic event, prolonged stay in the hospital and mortality.
Conclusion:
In this study, elevated levels of platelet to lymphocyte ratio were associated with mortality and morbidity after coronary artery bypass grafting operation.
