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Does Rigid Cystoscopy Affect the Total Serum Prostate-Specific Antigen Levels?

Iqbal Singh1, Ravi Prasad2, Vivek Agarwal3

  • 1Department of Surgery (Urology Division), University College of Medical Sciences (University of Delhi) and GTB Hospital, Delhi, 110095 India ; Department of Surgery (Urology), University College of Medical Sciences (University of Delhi), F-14 NDSE-2, New Delhi, 110049 India.

The Indian Journal of Surgery
|January 6, 2016
PubMed
Summary

Rigid cystoscopy (CPE) significantly elevates serum prostate-specific antigen (PSA) levels, persisting for over 24 hours. Healthcare providers should consider recent CPE history to avoid unnecessary prostate biopsies due to temporary PSA increases.

Keywords:
Check cystoscopyCystoscopyProstate-specific antigen

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Area of Science:

  • Urology
  • Clinical Chemistry

Background:

  • Serum prostate-specific antigen (PSA) is a key biomarker in urological diagnostics.
  • Elevated PSA levels can prompt further investigation, including prostate biopsies.
  • The impact of urological procedures on PSA levels requires careful consideration.

Purpose of the Study:

  • To prospectively evaluate the effect of rigid cystoscopy (CPE) on serum PSA levels in urological patients.
  • To determine the duration of PSA elevation following CPE.
  • To inform clinical interpretation of PSA values after cystoscopy.

Main Methods:

  • Prospective observational study involving 50 urological patients.
  • Serum PSA levels measured at baseline, 1-hour, and 24-hours post-CPE.
  • Statistical analysis using paired samples t-test.

Main Results:

  • Mean serum PSA levels showed a significant increase from baseline at 1-hour (p<0.001) and 24-hours (p<0.002) post-CPE.
  • The rise in PSA from 1-hour to 24-hours post-CPE was not statistically significant (p<0.043).
  • PSA levels demonstrated a variable rise persisting up to or beyond 24 hours after CPE.

Conclusions:

  • Rigid cystoscopy is associated with a significant and potentially prolonged elevation in serum PSA levels.
  • Clinicians should account for recent CPE when interpreting serum PSA values.
  • A waiting period of 24-48 hours post-CPE is advisable before PSA testing to avoid misinterpretation and unnecessary biopsies.