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Long-Term Evaluation of MEK Inhibitor Retinal Toxicity With Multimodal Imaging
Abstract:
MEK inhibitor chemotherapy, used in various malignancies, has been reported to be associated with serous retinal detachments. This study reports serial multimodal imaging focused primarily on infrared reflectance and spectral-domain optical coherence tomography (SD-OCT) in the monitoring of MEK inhibitor retinal toxicity. The benefit of OCT angiography in understanding the pathophysiology of MEK inhibitor toxicity is also shown.
Insights
MEK inhibitor chemotherapy can cause serous retinal detachments. Multimodal imaging, including infrared reflectance and SD-OCT, helps monitor this retinal toxicity and understand its pathology.
Area of Science:
- Ophthalmology
- Oncology
- Medical Imaging
Background:
- MEK inhibitor chemotherapy is utilized for various cancers.
- Serous retinal detachments are a known potential side effect of MEK inhibitors.
Observation:
- This study utilized serial multimodal imaging, emphasizing infrared reflectance and spectral-domain optical coherence tomography (SD-OCT).
- The research focused on monitoring MEK inhibitor-induced retinal toxicity.
Findings:
- Multimodal imaging, particularly SD-OCT, provides effective monitoring for MEK inhibitor retinal toxicity.
- OCT angiography aids in elucidating the pathophysiology of MEK inhibitor toxicity.
Implications:
- Enhanced understanding of MEK inhibitor ocular side effects.
- Improved monitoring strategies for patients undergoing MEK inhibitor therapy.
- Potential for earlier detection and management of retinal toxicity.
