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Updated: Mar 27, 2026

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A high-efficiency superhydrophobic plasma separator.

Changchun Liu1, Shih-Chuan Liao2, Jinzhao Song1

  • 1Department of Mechanical Engineering and Applied Mechanics, University of Pennsylvania, 210 Towne Building, 220 South 33rd St, Philadelphia, Pennsylvania 19104-6315, USA. lchangc@seas.upenn.edu.

Lab on a Chip
|January 7, 2016
PubMed
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This summary is machine-generated.

This study introduces a novel superhydrophobic plasma separator for efficient blood diagnostics. The device enables rapid, large-volume plasma separation from finger-prick blood, ideal for point-of-care applications.

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Clinical Diagnostics

Background:

  • Conventional plasma separation methods are unsuitable for point-of-care diagnostics.
  • Low abundance target molecules require large plasma volumes for detection.
  • Existing methods face limitations in speed, volume, and on-site applicability.

Purpose of the Study:

  • To develop a simple, high-efficiency plasma separator for large-volume separation from small blood samples.
  • To overcome limitations of conventional centrifugation for bedside diagnostics.
  • To enable rapid and efficient plasma separation for sensitive clinical assays.

Main Methods:

  • A clamshell-style, superhydrophobic plasma separator with a top-positioned membrane was designed.
  • Superhydrophobic surfaces were utilized to control blood film formation and minimize biomolecular adhesion.

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  • The device was tested for plasma separation efficiency and recovery of spiked genomic DNA.

    • Main Results:

    • The device achieved efficient plasma separation, yielding 65 ± 21.5 μL from 200 μL of whole blood in under 10 minutes.
    • Superhydrophobic properties enhanced plasma yield, reduced cell damage, and increased clotting time.
    • Over 84.5% recovery of Schistosoma mansoni genomic DNA was achieved in separated plasma.

    Conclusions:

    • The superhydrophobic plasma separator offers a promising solution for point-of-care diagnostics requiring large plasma volumes.
    • The device's efficiency and ease of use facilitate sensitive molecular testing directly from finger-prick blood.
    • This technology has the potential to improve accessibility and speed of clinical diagnostics in resource-limited settings.