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Updated: Mar 27, 2026
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A New Straightforward Method for Lipophilicity logP Measurement using 19F NMR Spectroscopy
Published on: January 30, 2019
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A frequency translation approach for multichannel (13)C spectroscopy.
Summary
Frequency translation enables narrow-band receivers to detect signals from multiple nuclei, overcoming limitations in multinuclear magnetic resonance imaging (MRI) and improving sensitivity for in vivo NMR studies.
Area of Science:
- Magnetic Resonance Imaging (MRI)
- Nuclear Magnetic Resonance (NMR) Spectroscopy
Background:
- Multi-channel MRI receivers typically operate on a narrow bandwidth, limiting their use to proton (1H) imaging.
- The growing interest in in vivo NMR necessitates improved sensitivity for nuclei beyond protons.
- A scarcity of multi-channel, multinuclear receivers hinders the development of advanced receive arrays.
Purpose of the Study:
- To address the limitations of narrow-band receivers in multinuclear applications.
- To adapt existing narrow-band receivers for broader multinuclear use in MRI and NMR.
- To facilitate improved sensitivity for in vivo NMR studies of various nuclei.
Main Methods:
- Utilizing frequency translation via radiofrequency mixers.
- Converting received signals from multinuclear arrays to the proton (1H) frequency.
- Adapting narrow-band receivers for multinuclear signal detection.
Main Results:
- Frequency translation effectively adapts narrow-band receivers for multinuclear operation.
- The method is compatible with a wide range of nuclei.
- Proton decoupling, essential for carbon-13 (13C) studies, is easily accommodated.
Conclusions:
- Frequency translation offers a viable solution for developing multi-channel, multinuclear receivers.
- This technique enhances the utility of existing MRI hardware for advanced NMR applications.
- It paves the way for improved in vivo NMR sensitivity and broader nucleus exploration.
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