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[Intrinsic factors, genes, and skin aging].

E Makrantonaki1,2, G P Pfeifer3, C C Zouboulis4

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Skin aging involves genetic and environmental factors impacting skin health. Understanding these mechanisms aids in preventing age-related diseases and extending lifespan.

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Area of Science:

  • Dermatology and aging research.
  • Molecular biology and genetics of skin.
  • Epigenetics and skin homeostasis.

Background:

  • Skin aging results from intrinsic and extrinsic factors.
  • Genetic and epigenetic modifications significantly influence skin aging.
  • Understanding aging mechanisms is key to preventing age-related diseases.

Purpose of the Study:

  • To summarize new knowledge on genes affecting skin aging.
  • To explore biological processes influencing skin homeostasis in old age.
  • To connect aging mechanisms with morphological and physiological skin changes.

Main Methods:

  • Literature review of recent studies on skin aging.
  • Analysis of genetic and epigenetic factors in skin aging.
  • Synthesis of information on biological pathways affecting skin.

Main Results:

  • Identified key genes and biological processes impacting aged skin.
  • Highlighted the role of genetic changes in skin aging.
  • Summarized the link between molecular changes and skin characteristics.

Conclusions:

  • New insights into skin aging mechanisms are available.
  • Understanding these processes can help extend healthy lifespan.
  • This knowledge contributes to preventing age-related skin conditions.