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[Experimental models of human skin aging]

G Nikolakis1,2, C Zoschke3, E Makrantonaki1,4

  • 1Klinik für Dermatologie, Venerologie und Allergologie, Immunologisches Zentrum, Städtisches Klinikum Dessau, Auenweg 38, 06847, Dessau, Deutschland.

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|January 9, 2016
PubMed

Insights

Human skin aging affects physiology and drug interactions. This review explores experimental models to improve understanding and develop better anti-aging strategies for skin research.

Area of Science:

  • Dermatology
  • Gerontology
  • Pharmacology

Background:

  • Skin serves as a key model for studying human aging processes.
  • Skin physiology undergoes significant changes throughout the lifespan.
  • The impact of aging on skin structure and DNA damage on drug efficacy remains poorly understood.

Purpose of the Study:

  • To review the current scientific knowledge on experimental models of human skin aging.
  • To highlight advancements in improving organotypic skin models.
  • To outline strategies for developing predictive aging models and enhancing aging research.

Main Methods:

  • Literature review of experimental models for human skin aging.
  • Analysis of current research on organotypic skin models.
  • Exploration of approaches for predictive aging modeling.

Main Results:

  • Identified knowledge gaps regarding age-related DNA damage and skin structure changes on pharmacological parameters.
  • Summarized the state of scientific knowledge in experimental models of human skin aging.
  • Presented approaches to enhance organotypic skin models and develop predictive aging models.

Conclusions:

  • Improved experimental skin models are crucial for understanding aging.
  • Further research is needed to elucidate the effects of skin aging on drug parameters.
  • Advancements in modeling can significantly improve the study of human skin aging.
Keywords:
DNA damageDrugsModels, animalOrganotypic skin modelsSkin physiology

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