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Updated: Mar 27, 2026

Modeling Mitochondrial Disease Using Brain Organoids: A Focus on Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes
Published on: October 10, 2025
[Thiamine deficiency caused lactic acidosis in patient with malnutrition]
Karin Nordholme1, Haval Othman2, Maria Cronhjort2
1Södersjukhuset - ane-iva STOCKHOLM, Sweden Södersjukhuset - ane-iva STOCKHOLM, Sweden.
Abstract:
A case is presented, where preoperative malnutrition was the most likely explanation to elevated lactate levels during and after surgery. Poor circulation, a common cause of elevated lactate during surgery, was excluded. The elevated lactate levels were normalized after intravenous administration of thiamine. Thiamine is an essential cofactor in carbohydrate metabolism for energy production. Thiamine deficiency is common among ICU patients. Clinical suspicion of malnutrition should lead to early parenteral administration of thiamine without specific laboratory confirmation of thiamine deficiency.
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