Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Syphilis.

S A Larsen1

  • 1Treponemal Pathogenesis and Immunobiology Branch, Centers for Disease Control, Atlanta, Georgia.

Clinics in Laboratory Medicine
|September 1, 1989
PubMed
Summary
This summary is machine-generated.

Diagnosing syphilis involves serologic tests and direct microscopic observation of Treponema pallidum. Laboratory professionals play a key role in ensuring the quality control of these syphilis diagnostic tests.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Aging-dependent changes in the effect of daily melatonin supplementation on rat metabolic and behavioral responses.

Journal of pineal research·2001
Same author

Chronic daily ethanol and withdrawal: 1. Long-term changes in the hypothalamo-pituitary-adrenal axis.

Alcoholism, clinical and experimental research·2001
Same author

Enzyme-linked immunospot assay for the diagnosis of active Treponema pallidum infection during the various stages of syphilis.

Sexually transmitted diseases·1999
Same author

Quality assessment activities in Latin America and the Caribbean.

MLO: medical laboratory observer·1997
Same author

Cross-reactivity to Borrelia burgdorferi proteins in serum samples from residents of a tropical country nonendemic for Lyme disease.

The Journal of infectious diseases·1997
Same author

Mseleni joint disease: not a borreliosis.

Transactions of the Royal Society of Tropical Medicine and Hygiene·1997
Same journal

Advances in Hemostasis Laboratory Testing.

Clinics in laboratory medicine·2026
Same journal

Extracellular Vesicles in Hemostasis.

Clinics in laboratory medicine·2026
Same journal

Thrombin Generation Assay: Ready for Prime Time.

Clinics in laboratory medicine·2026
Same journal

Viscoelastic Testing for the Laboratorian: Recent Advances and Practical Advice.

Clinics in laboratory medicine·2026
Same journal

Practical Recommendations for Harmonization of Hemostasis Testing Across Hospital Sites.

Clinics in laboratory medicine·2026
Same journal

The Role of Hypoxia in Vascular Endothelial Dysfunction and Venous Thromboembolism.

Clinics in laboratory medicine·2026
See all related articles

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Clinical Diagnostics

Background:

  • Syphilis diagnosis can be challenging due to its diverse clinical presentations mimicking other conditions.
  • Accurate identification of Treponema pallidum is crucial for effective syphilis management.
  • Standardized diagnostic protocols are essential for reliable syphilis detection.

Purpose of the Study:

  • To outline the diagnostic methods for syphilis.
  • To emphasize the importance of laboratory techniques in confirming syphilis infections.
  • To highlight the role of quality control in syphilis testing.

Main Methods:

  • Serologic testing, typically a two-step approach involving nontreponemal screening followed by treponemal confirmation.
  • Direct microscopic observation of Treponema pallidum using darkfield microscopy or immunofluorescent staining.

Related Experiment Videos

  • Examination of clinical specimens such as lesions, biopsies, or autopsy samples.

    • Main Results:

    • Syphilis diagnosis relies on a combination of clinical suspicion and laboratory confirmation.
    • Microscopic methods allow for direct visualization of the causative agent, Treponema pallidum.
    • Serologic testing provides a sensitive and specific means of detecting syphilis infection.

    Conclusions:

    • Effective syphilis diagnosis requires a comprehensive approach integrating clinical and laboratory findings.
    • Microscopic and serologic tests are vital tools for confirming syphilis.
    • Ongoing quality control by laboratorians is paramount for maintaining the accuracy of syphilis diagnostic tests.