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Updated: Mar 27, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
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Published on: August 25, 2014

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The Search for Biomarkers of Long-Term Outcome after Preterm Birth

James R C Parkinson, Matthew J Hyde, Neena Modi

    Nestle Nutrition Institute Workshop Series
    |January 15, 2016
    PubMed

    Insights

    Preterm birth increases risks for adult health problems, including chronic diseases and reduced lifespan. Identifying reliable biomarkers early is crucial for interventions to improve long-term health outcomes in survivors.

    Area of Science:

    • Perinatology and Developmental Origins of Health and Disease (DOHaD)

    Background:

    • Global increases in preterm birth necessitate safeguarding long-term health in survivors.
    • Preterm birth is associated with increased risks for adult morbidities, reproductive issues, and reduced longevity.
    • The specific contributions of genetics, intrauterine environment, and postnatal care to altered adult health trajectories remain unclear.

    Purpose of the Study:

    • To highlight the need for early detection and intervention strategies to mitigate adverse adult health outcomes following preterm birth.
    • To emphasize the importance of identifying stable biomarkers predictive of long-term functional health from infancy through adulthood.
    • To explore the potential of high-throughput 'omic' technologies in discovering novel biomarkers for health risk assessment.

    Main Methods:

    • Review of epidemiological and other studies linking preterm birth to adverse adult health.
    • Discussion of criteria for a satisfactory outcome biomarker: predictive of functional health and stable across the lifespan.
    • Proposal for large, longitudinal cohort studies integrating serial metabolomic profiling with life-course functional health assessments.

    Main Results:

    • Blood pressure is identified as the current best index fulfilling criteria for a stable, predictive health biomarker.
    • High-throughput 'omic' technologies hold promise for identifying new biomarkers of outcome and health risk.
    • Realizing the potential of 'omic' technologies requires significant investment in longitudinal cohort studies.

    Conclusions:

    • Early detection and intervention are essential to improve long-term health trajectories for preterm infants.
    • Longitudinal studies combining metabolomics and functional health assessments are critical for biomarker discovery and validation.
    • Investment in such research is vital to translate 'omic' potential into actionable strategies for safeguarding adult health.

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