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Minimally Invasive Isolated Limb Perfusion (MI-ILP) for Locally Advanced Melanomas and Sarcomas of the Extremity
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Neoadjuvant use of ipilimumab in locally advanced melanoma

Lynn J Howie1,2, Douglas S Tyler2, April K S Salama1,3

  • 1Division of Medical Oncology, Duke University, Trinity, North Carolina.

Journal of Surgical Oncology
|January 16, 2016
PubMed

Recent advances in immune modulating therapies show great promise for patients with advanced melanoma, however optimal strategies for achieving long-term disease control in locally advanced melanoma are unclear. We present two cases of neoadjuvant ipilimumab, one case in combination with isolated limb infusion (ILI) followed by surgical resection and one followed by surgery alone. Both patients have had durable responses. These cases highlight the ongoing need for prospective trials in the neoadjuvant setting.

Keywords:
immunotherapyipilimumabmelanomaneoadjuvant

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