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Updated: Mar 27, 2026

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
Published on: August 28, 2018
Interventional Options for Coronary Artery Calcification
Matthew I Tomey1, Samin K Sharma2
1Icahn School of Medicine at Mount Sinai, Cardiovascular Institute, One Gustave L. Levy Place, Box 1030, New York, NY, 10029, USA.
Insights
Severe coronary artery calcification hinders percutaneous coronary intervention. Advances in atheroablation now enable successful treatment of calcified lesions with improved safety.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Atherosclerosis Research
Background:
- Coronary artery calcification (CAC) is a key component of atherosclerosis.
- Moderate to severe CAC poses significant challenges during percutaneous coronary intervention (PCI).
- Historically, PCI for calcified lesions had lower success rates and higher complication risks.
Purpose of the Study:
- To provide an updated overview of CAC pathobiology.
- To review current interventional management strategies for calcified coronary lesions.
Main Methods:
- Focused review of existing literature on CAC and PCI techniques.
- Discussion of atheroablation technologies such as rotational and orbital atherectomy.
Main Results:
- Atheroablation technologies have significantly improved PCI success rates for calcified lesions.
- Current techniques offer a favorable safety profile for managing complex calcified coronary lesions.
Conclusions:
- PCI for calcified coronary lesions is now feasible with high success and safety.
- Advances in atheroablation have transformed the management of complex coronary artery disease.
Abstract:
Coronary artery calcification is an integral process in atherogenesis. When it is moderate or severe, coronary artery calcification presents several challenges to percutaneous coronary intervention. Historically, these difficulties have caused percutaneous coronary intervention of calcified lesions to be associated with lower rates of procedural success, higher rates of angiographic complications, and higher rates of subsequent adverse cardiovascular events. With growth of technologies and maturation of technique for atheroablation, in particular rotational atherectomy and orbital atherectomy, percutaneous coronary intervention of calcified coronary lesions has become possible with an extremely high success rate and a favorable safety profile. In this focused review, we present an updated overview of the pathobiology of coronary artery calcification and discuss the current slate of options for interventional management of calcified coronary lesions.
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