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Genetic polymorphisms associated with heart failure: A literature review
Mengqi Guo1, Guanlun Guo2, Xiaoping Ji3
1Key Laboratory of Cardiovascular Remodeling and Function Research, Department of Cardiology, Qilu Hospital, Shandong University, Jinan, China.
The Journal of International Medical Research
|January 16, 2016
Summary
Genetic variants linked to heart failure risk and outcomes show controversial results. Multiple genetic factors may interact to cause heart failure, requiring further investigation.
Area of Science:
- Cardiovascular Genetics
- Genomics in Medicine
Background:
- Heart failure is a complex condition with significant morbidity and mortality.
- Genetic factors are increasingly recognized as contributing to heart failure development and progression.
Purpose of the Study:
- To systematically review genetic association studies on heart failure.
- To examine reported associations between genetic variants and heart failure risk, therapeutic response, and prognosis.
Main Methods:
- A systematic literature search was conducted across PubMed, Web of Science, and CNKI databases.
- Studies published between January 1995 and February 2015 were included.
Main Results:
- Eighty-two articles were identified for review.
- These articles investigated associations involving 29 genes and 39 distinct polymorphisms.
- Findings across studies were often contradictory.
Conclusions:
- Genetic association studies in heart failure are characterized by significant controversy.
- The development of heart failure may involve complex interactions or synergistic effects of multiple genetic variants.
- Further research is needed to elucidate the precise role of gene-gene interactions in heart failure pathogenesis.
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