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Chloroquine resistant falciparum malaria in children

T H Rampengan, J Rampengan

    Paediatrica Indonesiana
    |January 1, 1989
    PubMed

    Insights

    Chloroquine resistance in falciparum malaria was observed in 28.6% of pediatric patients in Manado. Fansidar effectively treated chloroquine-resistant malaria cases, indicating a need for alternative antimalarial drugs.

    Area of Science:

    • Tropical Medicine
    • Infectious Diseases
    • Pediatrics

    Background:

    • Falciparum malaria remains a significant global health concern, particularly in regions with developing healthcare infrastructure.
    • Chloroquine has historically been a first-line treatment, but widespread resistance necessitates ongoing surveillance and evaluation of alternative therapies.

    Purpose of the Study:

    • To assess the prevalence of chloroquine resistance in pediatric falciparum malaria cases in Manado.
    • To evaluate the efficacy of Fansidar as a treatment for chloroquine-resistant falciparum malaria in children.

    Main Methods:

    • A retrospective study of 79 pediatric patients treated for falciparum malaria between March 1981 and August 1985.
    • Patients were assessed for chloroquine resistance using WHO standard field tests or a 7-day test.
    • Patients with confirmed chloroquine resistance (Resistance II) were subsequently treated with Fansidar.

    Main Results:

    • Twenty-one out of 79 patients (26.6%) met the criteria for chloroquine resistance.
    • Six of these patients (28.6% of resistant cases) exhibited Resistance II to chloroquine.
    • The average duration of fever in patients with Resistance II chloroquine malaria was 3.3 days (range 2-7 days).
    • All 6 patients with Resistance II chloroquine malaria were successfully treated with Fansidar.

    Conclusions:

    • A significant proportion of pediatric falciparum malaria cases in this cohort demonstrated chloroquine resistance.
    • Fansidar proved to be an effective treatment for chloroquine-resistant falciparum malaria (Resistance II) in children.
    • These findings underscore the importance of monitoring antimalarial drug resistance and considering alternative treatment regimens.

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