Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell Migration01:19

Cell Migration

7.3K
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
7.3K
Cell Migration01:09

Cell Migration

19.1K
Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
19.1K
Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

5.7K
A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
5.7K
Gastrulation01:56

Gastrulation

68.9K
Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
68.9K
Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

6.1K
Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
6.1K
Cell Polarization by Rho Proteins01:21

Cell Polarization by Rho Proteins

4.0K
Cell polarity is the asymmetric distribution of cellular and membrane components, making one side of the cell different from the other. This polarity is essential to many processes such as embryogenesis, axon migration, glucose transport across epithelial cells, and directional cell migration. A migrating cell responds to intracellular or extracellular signals via molecular cascades that reorganize the actin cytoskeleton to establish this polarity. In these cells, the Rho family proteins Cdc42,...
4.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nuclear adaptation in cell migration.

Current opinion in cell biology·2026
Same author

DySTrack - a modular smart microscopy tool for live tracking of dynamic samples on modern commercial microscopes.

Journal of cell science·2026
Same author

Response to: "Neonatal Autonomic and Adrenocorticotropic Features in the Offspring of Mothers in the Gestational Diabetes".

Archives of medical research·2026
Same author

Force coordination distinguishes epithelial and mesenchymal modes of collective chemotaxis.

The Journal of cell biology·2026
Same author

Celebrating a century of the Spemann-mangold experiment: Self-organisation in biology.

Cells & development·2025
Same author

Late Vitamin K Deficiency Bleeding in Infancy: The Time to Ensure Effective Prevention.

Nutrition reviews·2025
Same journal

Synergistic assembly, disassembly, and protection of complex forms of bundled F-actin.

The Journal of cell biology·2026
Same journal

Recruitment and release of XPG during NER is controlled by pre- and post-incision factors and EXO1.

The Journal of cell biology·2026
Same journal

Meiotic CENP-C supports centromere assembly and kinetochore recruitment in spermatogenesis.

The Journal of cell biology·2026
Same journal

Phosphatidylserine and RhoB connect PI4P and PA metabolism to maintain plasma membrane identity.

The Journal of cell biology·2026
Same journal

PIKfyve influences inter-organelle contacts with lysosomes to modulate the endoplasmic reticulum.

The Journal of cell biology·2026
Same journal

Sequential changes in calcium transients during M phase regulate cardiomyocyte proliferation.

The Journal of cell biology·2026
See all related articles

Related Experiment Video

Updated: Mar 27, 2026

Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration
10:53

Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration

Published on: October 13, 2019

7.6K

Collective cell migration in development.

Elena Scarpa1, Roberto Mayor2

  • 1Department of Cell and Developmental Biology, University College London, London WC1E 6BT, England, UK.

The Journal of Cell Biology
|January 20, 2016
PubMed
Summary
This summary is machine-generated.

Embryonic tissues rearrange via collective cell migration, guided by microenvironmental cues and cell-cell adhesion. This review explores mechanisms driving tissue development and morphogenesis.

More Related Videos

Using the Dot Assay to Analyze Migration of Cell Sheets
09:42

Using the Dot Assay to Analyze Migration of Cell Sheets

Published on: December 5, 2017

7.3K
Study of Cell Migration in Microfabricated Channels
09:36

Study of Cell Migration in Microfabricated Channels

Published on: February 21, 2014

12.5K

Related Experiment Videos

Last Updated: Mar 27, 2026

Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration
10:53

Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration

Published on: October 13, 2019

7.6K
Using the Dot Assay to Analyze Migration of Cell Sheets
09:42

Using the Dot Assay to Analyze Migration of Cell Sheets

Published on: December 5, 2017

7.3K
Study of Cell Migration in Microfabricated Channels
09:36

Study of Cell Migration in Microfabricated Channels

Published on: February 21, 2014

12.5K

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Biophysics

Background:

  • Embryonic development involves significant tissue rearrangements for germ layer positioning, patterning, and organ formation.
  • Collective cell migration is a key mechanism driving these morphogenetic movements in developing tissues.

Purpose of the Study:

  • To review recent advances in understanding the molecular and biomechanical mechanisms of collective cell migration during embryonic development.
  • To focus on the interplay between cells, microenvironmental guidance cues, and cell-cell adhesion.

Main Methods:

  • Review of existing literature on collective cell migration in various developmental models.
  • Analysis of studies investigating cellular interactions with the microenvironment.
  • Examination of the role of cell-cell adhesion in coordinating cell behavior.

Main Results:

  • Collective cell migration relies on coordinated cell movements.
  • Microenvironmental cues guide migrating cells.
  • Cell-cell adhesion is crucial for mechanical and behavioral coupling within migrating cell collectives.

Conclusions:

  • Understanding collective cell migration is vital for comprehending embryonic development and morphogenesis.
  • Future research should further elucidate the interplay of external cues and internal cell-cell interactions.