New composite materials based on alginate and hydroxyapatite as potential carriers for ascorbic acid.

Area of Science:

• Biomaterials Science
• Drug Delivery Systems
• Materials Chemistry

Background:

• Hydroxyapatite (HA) and alginate are biocompatible materials investigated for medical applications.
• These materials exhibit bioactivity, biocompatibility, and osteoconductivity.
• Controlled drug release systems are crucial for targeted therapeutic delivery.

Purpose of the Study:

• To create prolonged drug release systems for ascorbic acid (AA).
• To utilize hydroxyapatite (HA) and alginate as composite supports for drug delivery.
• To investigate the influence of varying alginate and hydroxyapatite ratios on drug release.

Main Methods:

• Synthesis of three Alg/HA/AA composites with different mass ratios (1:1, 1:3, 3:1).
• Characterization using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM).
• Drug release kinetics observed via UV-Vis spectroscopy.

Main Results:

• Successful synthesis of alginate-hydroxyapatite composites loaded with ascorbic acid.
• Characterization confirmed the composite structures and material properties.
• Preliminary data on drug release profiles from the different composite ratios were obtained.

Conclusions:

• Alginate-hydroxyapatite composites offer a viable platform for controlled ascorbic acid delivery.
• The ratio of alginate to hydroxyapatite influences the drug release characteristics.
• Further research can optimize these composites for enhanced therapeutic efficacy.