Related Experiment Video
Updated: Mar 26, 2026
08:49
Author Spotlight: Unveiling the Potential of VSFG Microscopy in Studying Mesoscopically Heterogeneous Self-Assembled Structures
Published on: December 1, 2023
2.2K
Spatially resolved spectroscopy using tapered stripline NMR.
Koen C H Tijssen1, Jacob Bart1, Roald M Tiggelaar2
1Institute for Molecules and Materials, Radboud University, Nijmegen, The Netherlands.
Journal of Magnetic Resonance (San Diego, Calif. : 1997)
|January 23, 2016
Summary
This study introduces a novel method for generating radiofrequency (RF) B1 field gradients using tapered stripline coils in Nuclear Magnetic Resonance (NMR). This technique enables advanced NMR applications, including micro-volume imaging and fast reaction monitoring.
Area of Science:
- Physics
- Chemistry
- Engineering
Background:
- Magnetic field B0 gradients are crucial for Nuclear Magnetic Resonance (NMR) spectroscopy and imaging.
- Existing methods for generating RF/B1 gradients face practical design limitations.
Purpose of the Study:
- To present a new method for creating arbitrary B1 field gradients using stripline RF coils.
- To demonstrate the utility of this method in various NMR applications.
Main Methods:
- Utilizing the correlation between conductor width and RF field strength in stripline NMR chips.
- Tapering stripline chips to engineer specific B1 field gradient shapes.
- Characterizing the tapered stripline configuration.
Main Results:
- Demonstrated successful generation of arbitrary B1 field gradients.
- Showcased applications in nL-μL volume magnetic resonance imaging.
- Enabled monitoring of fast chemical reactions (10^-2–10^1 s).
- Achieved high-resolution spectra compensation in inhomogeneous B0 fields.
Conclusions:
- Tapered stripline RF coils offer a practical solution for generating B1 gradients.
- This method significantly expands the capabilities of NMR spectroscopy and imaging.
Related Concept Videos
01:14NMR Spectrometers: Resolution and Error Correction
1.1K
When magnetic nuclei in a sample achieve resonance and undergo relaxation, the signal detected in NMR is an approximately exponential free induction decay. Fourier transform of an exponential decay yields a Lorentzian peak in the frequency domain. Lorentzian peaks in an NMR spectrum are defined by their amplitude, full width at half maximum, and position, where the peak width is governed by the spin-spin relaxation time alone. In real experiments, however, the applied magnetic field is rendered...
1.1K
01:12Two-Dimensional (2D) NMR: Overview
1.7K
The 1D NMR spectrum of large and complex molecules like natural products has complicated splitting patterns and overlapping signals, which can be easily interpreted using 2-dimensional (2D) NMR. Unlike 1D NMR, 2D NMR has two frequency axes that provide the coupling information between the nucleus A and nucleus B in a molecule. The process from which 2D spectra are obtained has four steps.
The first step is the preparation period, during which nucleus A is excited with a radiofrequency pulse....
The first step is the preparation period, during which nucleus A is excited with a radiofrequency pulse....
1.7K
01:20NMR Spectrometers: Overview
2.5K
NMR spectrometers consist of a strong magnet, a radiofrequency transmitter, and a detector attached to a computer console for recording spectra of samples containing NMR-active nuclei. In first-generation NMR instruments called continuous-wave spectrometers, the resonance frequencies of the nuclei are determined by frequency-sweep or field-sweep methods. The magnetic field strength is fixed and the rf signal is swept in the former, while the radiofrequency signal is fixed and the magnetic field...
2.5K
01:02¹H NMR: Interpreting Distorted and Overlapping Signals
1.7K
Spin systems where the difference in chemical shifts of the coupled nuclei is greater than ten times J are called first-order spin systems. These nuclei are weakly coupled, and their chemical shifts and coupling constant can generally be estimated from the well-separated signals in the spectrum.
As Δν decreases and the signals move closer, the doublets appear increasingly distorted. The intensities of the inner lines increase at the cost of those of the outer lines as the signals are...
As Δν decreases and the signals move closer, the doublets appear increasingly distorted. The intensities of the inner lines increase at the cost of those of the outer lines as the signals are...
1.7K
01:04¹³C NMR: ¹H–¹³C Decoupling
2.1K
The probability of having two carbon-13 atoms next to each other is negligible because of the low natural abundance of carbon-13. Consequently, peak splitting due to carbon-carbon spin-spin coupling is not observed in spectra. However, protons up to three sigma bonds away split the carbon signal according to the n+1 rule, resulting in complicated spectra.
A broadband decoupling technique is used to simplify these complex, sometimes overlapping, signals. Broadband decoupling relies on a...
A broadband decoupling technique is used to simplify these complex, sometimes overlapping, signals. Broadband decoupling relies on a...
2.1K
01:12Double Resonance Techniques: Overview
848
Double resonance techniques in Nuclear Magnetic Resonance (NMR) spectroscopy involve the simultaneous application of two different frequencies or radiofrequency pulses to manipulate and observe two distinct nuclear spins. One important application of double resonance is spin decoupling, which selectively suppresses coupling with one type of nucleus while observing the NMR signal from another nucleus, simplifying the spectrum and enhancing resolution.
Spin decoupling is usually achieved by...
Spin decoupling is usually achieved by...
848