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Updated: Jul 26, 2026

Assessment of Mitochondrial Functions and Cell Viability in Renal Cells Overexpressing Protein Kinase C Isozymes
Published on: January 7, 2013
Lack of correlation between translocation and biological effects mediated by protein kinase C: an appraisal
Abstract:
Protein kinase C is involved in the mechanism of action of hormones, growth factors, mitogens and tumour promoters. The correlation between the extent of the biological effects mediated by protein kinase C and its fractional activation shows cell type specific patterns of behaviour. The discrepancy between enzyme activity and biological effects elicited by protein kinase C is particularly relevant to lymphoblastic cells. In B cells, the full expression of some biological responses mediated by protein kinase C may be achieved by activation of less than 5% of the enzyme activity.
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