Related Experiment Video
Updated: Mar 26, 2026

Preparation of Peripheral Nerve Stimulation Electrodes for Chronic Implantation in Rats
Published on: July 14, 2020
[Implantable nerve stimulation for obstructive sleep apnea hypopnea syndrome]
Lidia Afonso Delgado1, Jean-Arthur Micoulaud Franchi2, Pierre-Jean Monteyrol3
1CHU de Bordeaux, pôle de neurosciences cliniques (PNC), place Amélie-Raba-Léon, 33076 Bordeaux, France.
Abstract:
Obstructive sleep apnea hypopnea syndrome (OSAHS) is a common disorder that has been identified as a contributor to cardiovascular disease making it a major public health problem. Continuous positive airway pressure is the standard treatment but compliance is suboptimal. Mandibular advancement devices and surgery have limited indications, inconstant efficiency and potential irreversible side effects. Stimulation of the hypoglossal nerve, that innervates the genioglossus, a protrusor muscle of the tongue, is now a new treatment option for moderate and severe cases of OSAHS. Two types of stimulation are currently available: stimulation synchronous with inspiration and continuous stimulation. The indication of each type of stimulation and long-term effects still need to be assessed but the implantable nerve stimulation is a promising treatment for patients without a therapy solution so far.

