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Perinatal Neuroprotection for Extremely Preterm Infants
Alexis S Davis1, Victoria K Berger2, Valerie Y Chock1
1Division of Neonatal-Developmental Medicine, Stanford University, Palo Alto, California.
American Journal of Perinatology
|January 23, 2016
Summary
Preventing preterm birth is ideal, but not always possible. This review covers obstetric and neonatal practices that protect the vulnerable preterm brain from injury.
Area of Science:
- Neuroscience
- Neonatology
- Obstetrics
Background:
- The preterm brain is susceptible to various injuries, including ischemia, hemorrhage, and inflammation.
- Aberrations in growth and development also impact the preterm brain.
- Preventing preterm birth is the primary neuroprotective strategy, but other interventions are crucial.
Purpose of the Study:
- To review obstetric and neonatal practices that offer neuroprotection to the developing preterm brain.
- To highlight strategies beyond preterm birth prevention for brain health.
Main Methods:
- Literature review of studies on neuroprotective strategies in preterm infants.
- Analysis of obstetric interventions.
- Analysis of neonatal care practices.
Main Results:
- Identified multiple mechanisms of preterm brain injury.
- Highlighted the importance of both obstetric and neonatal interventions.
- Emphasized the role of specific practices in mitigating brain damage.
Conclusions:
- While preventing preterm birth is key, specific obstetric and neonatal practices can significantly protect the preterm brain.
- A comprehensive approach combining prevention and targeted interventions is essential for optimal neurodevelopment in preterm infants.
