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Recent advances in co-amorphous drug formulations
Swapnil Jayant Dengale1, Holger Grohganz2, Thomas Rades2
1Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka, India.
Advanced Drug Delivery Reviews
|January 26, 2016
Summary
Co-amorphous drug delivery systems enhance oral bioavailability of poorly soluble drugs by improving dissolution. This approach uses low molecular weight components, reducing the need for amorphous stabilizers.
Area of Science:
- Pharmaceutical Science
- Materials Science
Background:
- Co-amorphous systems offer improved oral bioavailability for poorly water-soluble drugs.
- These systems enhance drug dissolution via their amorphous nature.
- They utilize only low molecular weight components, reducing stabilizer requirements.
Purpose of the Study:
- To provide an overview of co-amorphous drug delivery systems.
- To investigate co-amorphous formulations as solid dispersions.
- To analyze their formation, stabilization, and performance.
Main Methods:
- Review of recent scientific literature on co-amorphous formulations.
- Analysis of co-amorphous systems from a solid dispersion perspective.
- Evaluation of formation, stabilization mechanisms, dissolution, and in vivo performance.
Main Results:
- Co-amorphous systems demonstrate significant potential for drug dissolution enhancement.
- The use of low molecular weight co-formers simplifies stabilization compared to other techniques.
- These systems show promise for improving in vivo drug performance.
Conclusions:
- Co-amorphous formulations are a promising strategy for enhancing oral drug bioavailability.
- Further research into their formation, stabilization, and application is warranted.
- This approach offers a simplified method for amorphous stabilization in drug delivery.
Keywords:
Co-amorphousIncreased dissolutionMolecular interactionsPoorly soluble drugsSolid dispersionMore Related Videos
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