Related Experiment Video
Updated: Mar 26, 2026

Basic Research in Plasma Medicine - A Throughput Approach from Liquids to Cells
Published on: November 17, 2017
An investigation of the comparability of commercially sourced plasma and pharmaceutical study plasma, using total
Clive Felgate1, Neil Spooner1, Robert Calloway1
1GlaxoSmithKline, David Jack Centre, Research & Development, Park Road, Ware, Hertfordshire SG12 0DP, UK.
Background:
Control blood plasma is regularly used in bioanalysis, biomarkers and proteomics, and is often obtained from commercial sources. It has always been assumed that this plasma will be comparable to plasma drawn during a drug development study.
Results:
When compared using total protein concentrations, plasma from only one species (dog) demonstrated statistical comparability, plasma from all other species tested (human, rabbit, mouse and rat) shows a statistically significant difference.
Conclusion:
If endogenous components of blood plasma are being measured, or if an assay technique does not significantly limit matrix effects, any assay controls should be prepared using control plasma from the drug development site, or using commercial plasma that has been screened against drug development site plasma.
More Related Videos
Related Concept Videos
Drug Concentrations: Measurements
Plasma...
Drug Distribution: Plasma Protein Binding
Composition of Blood Plasma

