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Updated: Mar 26, 2026
Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites
Published on: May 18, 2016
Transdermal immunization of P. falciparum surface antigen (MSP-119) via elastic liposomes confers robust
Rajeev K Tyagi1,2, Neeraj K Garg3, Sarat K Dalai2
1a Department of Global Health , College of Public Health, University of South Florida , Tampa , FL , USA.
Abstract:
As transdermal immunization results in poor immunogenicity, which is attributed to poor permeability of antigens through the skin, we believed ultradeformable lipid vesicles (elastic liposome) might address the challenges encountered during transdermal immunization. The elastic liposome, versatile carrier, proves better vehicle for transcutaneous delivery of protein, peptide and nucleic acid antigens. Our recently published article (1) is suggestive of improved immunogenicity of carboxyl-terminal 19 kDa fragment of merozoite surface protein-1 (PfMSP-119) of Plasmodium falciparum when administered subcutaneously via elastic liposomes ( Fig. 1 ).
