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Carbamazepine-induced hypertension: A rare case
Preeti Kharb1, Niti Mittal1, Mahesh C Gupta1
1Department of Pharmacology, Pandit Bhagwat Dayal Sharma University of Health Sciences, Rohtak, Haryana, India.
Journal of Pharmacology & Pharmacotherapeutics
|January 28, 2016
Summary
Carbamazepine, used for trigeminal neuralgia, can rarely cause hypertension. Discontinuing the drug led to recovery, highlighting a potential adverse effect for healthcare professionals to monitor.
Area of Science:
- Neurology
- Pharmacology
- Cardiology
Background:
- Trigeminal neuralgia is a chronic pain condition.
- Carbamzepine is a common medication for trigeminal neuralgia.
- Hypertension is a prevalent cardiovascular condition.
Observation:
- A 74-year-old female with trigeminal neuralgia experienced new-onset hypertension after starting carbamazepine.
- The hypertension persisted despite antihypertensive treatments and carbamazepine dose reduction.
- Discontinuation of carbamazepine resulted in the resolution of hypertension.
Findings:
- A causal link was established between carbamazepine therapy and the development of hypertension.
- Positive dechallenge and rechallenge confirmed carbamazepine-induced hypertension.
- This represents a rare adverse effect of carbamazepine therapy.
Implications:
- Healthcare providers, particularly neurologists, should be aware of carbamazepine-induced hypertension.
- Monitoring blood pressure in patients initiating carbamazepine is crucial.
- This case underscores the importance of considering drug-induced adverse effects in clinical practice.
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