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An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
Published on: August 16, 2021
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Opportunities and Challenges for Host-Directed Therapies in Tuberculosis
Madhur Sachan, Ashish Srivastava, Rajeev Ranjan
1Pharmaceutics Division, CSIRCentral Drug Research Institute, Sector 10A, Janakipuram Extension, Lucknow 226031, India. amit_misra@cdri.res.in.
Current Pharmaceutical Design
|January 29, 2016
Summary
Host-targeted therapies (HDT) show promise for treating tuberculosis (TB) by modulating macrophage responses. Inhaled delivery systems are proposed as an optimal strategy to enhance HDT efficacy and safety for pulmonary TB.
Area of Science:
- Pulmonary medicine
- Immunology
- Drug delivery systems
Background:
- Tuberculosis (TB) remains a leading infectious cause of death, comparable to HIV.
- Host-targeted therapies (HDT) are emerging strategies to improve TB treatment outcomes, including for drug-resistant strains.
- HDT aims to enhance efficacy, shorten treatment duration, and preserve lung architecture in TB patients.
Purpose of the Study:
- To review pulmonary delivery strategies for enhancing the safety and efficacy of host-targeted therapies (HDT) against pulmonary tuberculosis (TB).
- To explore the potential of inhaled HDT for improving TB treatment.
- To synthesize findings on macrophage response modulation for TB therapy.
Main Methods:
- Literature review of publicly available data on pulmonary delivery of HDT for TB.
- Revisiting existing research results on inhaled HDT.
- Analysis of macrophage response pathways targeted by HDT.
Main Results:
- Host-targeted therapies (HDT) can modulate various macrophage responses, including intracellular factors, extracellular signals, phagolysosomes, autophagy, and apoptosis.
- Existing drugs approved for other conditions may be suitable for modulating these macrophage responses.
- Macrophage responses targeted include free radicals, antimicrobial peptides, cytokines, chemokines, inflammasomes, and apoptosis pathways.
Conclusions:
- Inhaled delivery systems targeting macrophages represent an optimal strategy for deploying host-targeted therapies (HDT) in tuberculosis (TB) treatment.
- Pulmonary delivery enhances the safety and efficacy of HDT for TB.
- Macrophage-targeted inhaled therapies offer a promising approach for managing TB.
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