Related Experiment Video
Updated: Mar 26, 2026

11:38
In vivo Imaging of Optic Nerve Fiber Integrity by Contrast-Enhanced MRI in Mice
Published on: July 22, 2014
14.0K
Methanol-induced toxic optic neuropathy with diffusion weighted MRI findings
Asli Tanrivermis Sayit1, Kerim Aslan1, Muzaffer Elmali1
1a Department of Radiology , Ondokuz Mayis University Faculty of Medicine , Samsun , Turkey and.
Cutaneous and Ocular Toxicology
|January 29, 2016
Summary
Methanol intoxication can cause optic nerve damage, as seen in a patient with blurred vision. Magnetic resonance imaging (MRI) revealed characteristic changes in the optic nerves, confirming methanol-induced optic neuropathy.
Area of Science:
- Neurology
- Toxicology
- Radiology
Background:
- Methanol intoxication is a serious condition that can lead to severe visual impairment.
- Early diagnosis and treatment are crucial to prevent permanent vision loss.
Observation:
- A 52-year-old male presented with blurred vision after consuming cologne containing methanol.
- Brain and orbital magnetic resonance imaging (MRI) was performed upon admission.
Findings:
- MRI revealed bilateral mild contrast enhancement in the retrobulbar optic nerves (RBONs).
- Diffusion-weighted imaging demonstrated restricted diffusion within the RBONs.
- These findings were indicative of methanol-induced optic neuropathy.
Implications:
- MRI findings can aid in diagnosing methanol-induced optic neuropathy.
- This case highlights the importance of neuroimaging in evaluating visual disturbances following methanol exposure.
- Prompt treatment, including ethanol, NaHCO3, and hemodialysis, is essential for managing methanol toxicity.

