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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Pigmentation01:19

Pigmentation

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The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
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The Retinoblastoma Gene01:20

The Retinoblastoma Gene

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The Retinoblastoma Gene01:20

The Retinoblastoma Gene

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Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
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Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
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Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
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Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
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Nevoid Melanoma.

A Hafeez Diwan1, Alexander J Lazar2

  • 1Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Suite 214B, MS: BCM 315, Houston, TX, USA; Department of Dermatology, Baylor College of Medicine, Houston, TX, USA; Department of Pathology, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe, Unit 85, Houston, TX, USA.

Surgical Pathology Clinics
|February 4, 2016
PubMed
Summary
This summary is machine-generated.

This article details nevoid melanoma, covering its gross and microscopic characteristics, diagnostic methods, and treatment options for better understanding and management.

Keywords:
Deceptive histologyDiagnostic pitfallsImmunohistochemical findingsMitotic figuresNevoid melanomaNuclear atypiaSmall cell melanoma

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Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Nevoid melanoma is a rare melanocytic neoplasm.
  • Accurate diagnosis is crucial for appropriate management.

Purpose of the Study:

  • To provide a comprehensive overview of nevoid melanoma.
  • To discuss key diagnostic and prognostic features.

Main Methods:

  • Review of literature on nevoid melanoma.
  • Discussion of histopathological and immunohistochemical findings.
  • Analysis of differential diagnoses.

Main Results:

  • Detailed description of gross and microscopic features.
  • Highlighting of immunohistochemical markers aiding diagnosis.
  • Comparison with similar entities for differential diagnosis.

Conclusions:

  • Nevoid melanoma requires careful evaluation of multiple features.
  • Accurate diagnosis impacts patient prognosis and treatment decisions.