Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is Cancer?02:12

What is Cancer?

15.5K
Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
15.5K
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

4.9K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.9K
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

2.8K
2.8K
Skin Cancer01:30

Skin Cancer

6.6K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
6.6K
Cancer Prevention02:59

Cancer Prevention

8.7K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
8.7K
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

6.6K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
6.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lung Adenocarcinoma and Genetic Cancer Predisposition in an Adolescent.

Pediatric blood & cancer·2026
Same author

An Atypical Presentation of Primary Mediastinal Germ Cell Tumor With Spontaneous Serum Tumor Marker Regression: A Case Report and Review of Diagnostic Considerations.

Pediatric blood & cancer·2026
Same author

BK Polyomavirus-Associated Kidney and Bladder Carcinomas Following Heart and Lung Transplantation in Childhood.

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·2026
Same author

Loss of expression of STK11/LKB1 in intratubular large cell hyalinizing Sertoli cell neoplasm.

Histopathology·2025
Same author

Violaceous, hyperkeratotic plaque in a pediatric patient.

JAAD case reports·2025
Same author

Thinking Fast: Addressing a Tachypneic Infant.

Pediatric pulmonology·2025
Same journal

Molecular Pathology in Contemporary Surgical Practice.

Surgical pathology clinics·2026
Same journal

Beyond Blood: Liquid biopsy assays for nonplasma body fluids.

Surgical pathology clinics·2026
Same journal

The Molecular Landscape of Ovarian Neoplasms: A Review.

Surgical pathology clinics·2026
Same journal

Clinically Relevant Molecular Pathology of Endometrial Cancer.

Surgical pathology clinics·2026
Same journal

Molecular Pathology of Genitourinary Tumors: Diagnostic, Prognostic, and Therapeutic Implications.

Surgical pathology clinics·2026
Same journal

Oncogenicity and Therapeutic Implications of Molecular Biomarkers in Colorectal Carcinoma.

Surgical pathology clinics·2026
See all related articles

Related Experiment Video

Updated: Mar 26, 2026

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

19.8K

Childhood Carcinoma.

Sara O Vargas1

  • 1Department of Pathology, Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.

Surgical Pathology Clinics
|February 4, 2016
PubMed
Summary
This summary is machine-generated.

Pediatric carcinomas are rare but distinct from adult cancers. Recent discoveries in chromosomal rearrangements are advancing their diagnosis and understanding.

Keywords:
BRD4-NUT carcinomaMyoepitheliomaPediatric carcinomaSalivary gland-type carcinomaSecretory breast carcinoma

More Related Videos

Cell Population Analyses During Skin Carcinogenesis
06:53

Cell Population Analyses During Skin Carcinogenesis

Published on: August 21, 2013

13.0K
Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

21.3K

Related Experiment Videos

Last Updated: Mar 26, 2026

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

19.8K
Cell Population Analyses During Skin Carcinogenesis
06:53

Cell Population Analyses During Skin Carcinogenesis

Published on: August 21, 2013

13.0K
Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

21.3K

Area of Science:

  • Oncology
  • Pathology
  • Genetics

Background:

  • Pediatric carcinomas are rare, differing significantly from adult carcinomas.
  • Recurrent chromosomal aberrations, particularly translocations, are well-established in pediatric sarcomas.
  • Identifying chromosomal rearrangements in pediatric carcinomas is a new diagnostic frontier.

Purpose of the Study:

  • To provide an overview of pediatric carcinoma.
  • To review specific pediatric carcinoma types that pose diagnostic challenges.
  • To illustrate emerging concepts in pediatric carcinoma diagnosis.

Main Methods:

  • Literature review of pediatric carcinoma.
  • Analysis of diagnostic challenges in specific pediatric carcinoma subtypes.
  • Discussion of novel molecular findings in pediatric carcinomas.

Main Results:

  • Pediatric carcinomas exhibit unique characteristics compared to adult counterparts.
  • Chromosomal rearrangements are increasingly recognized as key diagnostic markers in pediatric carcinomas.
  • Emerging molecular insights are refining the classification and diagnosis of these rare tumors.

Conclusions:

  • Understanding the distinct biology of pediatric carcinomas is crucial for accurate diagnosis.
  • Diagnostic advancements rely on identifying specific chromosomal aberrations.
  • Continued research into pediatric carcinoma genetics will improve patient outcomes.