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Related Concept Videos

Disorders of Leukocytes01:27

Disorders of Leukocytes

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Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
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Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
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Updated: Mar 26, 2026

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
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Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

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Systemic Mastocytosis.

Tracy I George1, Hans-Peter Horny2

  • 1Department of Pathology, Stanford University School of Medicine, Stanford University Medical Center, 300 Pasteur Drive, Room H1501B, Stanford, CA 94305-5627, USA.

Surgical Pathology Clinics
|February 4, 2016
PubMed
Summary
This summary is machine-generated.

Systemic mastocytosis is a neoplastic proliferation of mast cells that presents with diverse symptoms and appearances. This review aids pathologists in diagnosing this challenging condition by detailing its cytology, histopathology, and clinical features.

Keywords:
KIT D816VMast cellMast cell leukemiaSystemic mastocytosis

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Area of Science:

  • Pathology
  • Hematology
  • Oncology

Background:

  • Mastocytosis encompasses a spectrum of disorders characterized by abnormal mast cell accumulation.
  • Systemic mastocytosis (SM) involves mast cell infiltration of extracutaneous organs, presenting with varied clinical manifestations.
  • Recognizing SM is crucial due to its potential for significant morbidity and mortality.

Purpose of the Study:

  • To provide a comprehensive overview of systemic mastocytosis for pathologists.
  • To highlight diagnostic challenges, including morphologic variations and clinical heterogeneity.
  • To discuss prognostic implications and ancillary studies for accurate diagnosis.

Main Methods:

  • Review of literature on mastocytosis, focusing on diagnostic criteria and clinical presentations.
  • Analysis of cytologic and histopathologic features of systemic mastocytosis.
  • Discussion of clinical signs, symptoms, and prognostic factors.

Main Results:

  • Systemic mastocytosis exhibits diverse morphologic appearances and clinical presentations.
  • Key features include skin manifestations and signs of mast cell mediator release.
  • Diagnostic pitfalls and differentiating mimics are essential for accurate diagnosis.

Conclusions:

  • Accurate diagnosis of systemic mastocytosis requires integrating cytologic, histopathologic, and clinical findings.
  • Understanding diagnostic challenges and utilizing ancillary studies improves diagnostic accuracy.
  • Early and correct diagnosis is vital for appropriate patient management and prognosis.