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Light-mediated Formation and Patterning of Hydrogels for Cell Culture Applications
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Tissue-Integratable and Biocompatible Photogelation by the Imine Crosslinking Reaction
Yunlong Yang1, Jieyuan Zhang2, Zhenzhen Liu1
1Key Laboratory for Advanced Materials, Institute of Fine Chemicals, East China University of Science and Technology, 130# Meilong Road, Shanghai, 200237, China.
Abstract:
A novel photogelling mechanism by the phototriggered-imine-crosslinking (PIC) reaction is demonstrated. Hyaluronic acid grafted with o-nitrobenzene, a photogenerated aldehyde group, can quickly photo-crosslink with amino-bearing polymers or proteins. Once the in situ photogelling on a wound occurs, the PIC gelling process can well integrate a hydrogel with surrounding tissue by covalent bonding, thus making it a powerful tool for tissue engineering and regenerative medicine.
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