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Updated: Mar 26, 2026

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
Published on: May 21, 2015
What is wrong with the regulatory T cells and foetomaternal tolerance in women with recurrent miscarriages?
M H C Craenmehr1, S Heidt1, M Eikmans1
1Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.
Abstract:
Couples of whom the woman has had a miscarriage have two major concerns: the cause and possible risk of recurrence. Unfortunately, a significant proportion of cases of recurrent miscarriage (RM) remain unexplained despite detailed investigation. Because data suggest that regulatory T cells (Treg) are involved in the maternal acceptance of the allogeneic foetus, RM could possibly be explained by a disturbance of the Treg network. The possible role of Tregs in RM is described in this review, as well as their potential application in diagnostics and therapeutic intervention trials.
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