Related Experiment Video
Updated: Mar 26, 2026
05:21
Laparoscopic Extracorporeal Knot-Tying for Uterine Vessel Occlusion during Hysterectomy with Cervical Cerclage in Large Uteri
Published on: September 12, 2025
682
EFFECT OF PRE-OPERATIVE SUB-LINGUAL MISOPROSTOL VERSUS INTRAVENOUS OXYTOCIN ON CAESAREAN OPERATION BLOOD LOSS
P O Adefuye1, R A Akindele, B O Adefuye
1Department of Obstetrics and Gynaecology, Olabisi Onabanjo University Teaching Hospital, Sagamu, Ogun State, Nigeria.
East African Medical Journal
|February 9, 2016
Summary
Pre-operative sub-lingual misoprostol significantly reduces blood loss during Caesarean operations compared to standard oxytocin. While effective, misoprostol use was associated with more transient side effects like chills and fever.
Area of Science:
- Obstetrics and Gynecology
- Pharmacology
Background:
- Caesarean operations are common, with hemorrhage being a significant risk.
- Effective methods to minimize blood loss are crucial for patient safety.
Purpose of the Study:
- To compare pre-operative sub-lingual misoprostol with post-operative intravenous oxytocin for reducing blood loss during Caesarean sections.
Main Methods:
- A prospective study was conducted to evaluate the effectiveness of the two interventions.
Main Results:
- The misoprostol group showed significantly lower mean blood loss (517.32ml) than the oxytocin group (621.22ml).
- A significantly lower drop in hematocrit was observed in the misoprostol group (1.88) compared to the oxytocin group (3.04).
- Transient side effects including chills, shivering, and pyrexia were more frequent with misoprostol.
Conclusions:
- Pre-operative sub-lingual misoprostol is more effective in reducing blood loss during Caesarean sections than intravenous oxytocin.
- Misoprostol use is associated with a higher incidence of transient side effects such as chills, shivering, and pyrexia.
